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Definition of original RECIP incorporated quantitative changes of PSMA-VOL calculated using semi-automatic software for whole-body tumor segmentation in PSMA PET. However, this process can still be time consuming with an average time of 10 minutes per scan. Hence, quantification of PSMA-VOL is not feasible yet for use in daily practice. Nevertheless, standardized treatment response evaluation in metastatic prostate cancer in clinical routine using next-generation PSMA imaging is an urgent need. In a recent study published in Radiology, RECIP investigators found that changes in PSMA-VOL determined visually by five board-certified nuclear medicine physicians had 95% correlation with quantitative changes in PSMA-VOL calculated using semi-automatic tumor segmentation software. These findings suggest that RECIP assessed by nuclear medicine physicians (Practical RECIP) can be used in daily practice.

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